Michael R Wessels Selected Research

NAD+ Nucleosidase (NAD(P) Nucleosidase)

1/2022	Structure of the Streptococcus pyogenes NAD+ Glycohydrolase Translocation Domain and Its Essential Role in Toxin Binding to Oropharyngeal Keratinocytes.
12/2017	Binding of NAD+-Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A Streptococcus.
1/2017	Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD+-Glycohydrolase: Evidence for Extracellular Activity.
3/2016	NAD+-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus.
9/2014	Streptolysin O and NAD-glycohydrolase prevent phagolysosome acidification and promote group A Streptococcus survival in macrophages.
1/2013	Streptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from Xenophagic killing.
10/2005	Role of NADase in virulence in experimental invasive group A streptococcal infection.

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Michael R Wessels Research Topics

Disease

16	Infections 01/2022 - 01/2003
2	Streptococcal Infections (Streptococcal Infection) 01/2022 - 10/2005
2	Sepsis (Septicemia) 10/2005 - 11/2003
2	Pneumococcal Infections 10/2005 - 02/2003
1	Hemolysis 01/2022
1	Pain (Aches) 01/2018
1	Necrotizing Fasciitis 01/2018
1	Pharyngitis (Sore Throat) 01/2013
1	Soft Tissue Infections 10/2005
1	Meningitis 11/2003

Drug/Important Bio-Agent (IBA)

7	NAD+ Nucleosidase (NAD(P) Nucleosidase)IBA 01/2022 - 10/2005
3	Polysaccharides (Glycans)IBA 01/2022 - 05/2005
2	streptolysin OIBA 01/2022 - 01/2003
2	Capsules (Microcapsules)IBA 01/2019 - 10/2008
2	streptolysin SIBA 01/2018 - 01/2003
2	Virulence Factors (Pathogenicity Factors)IBA 10/2012 - 10/2008
2	CathelicidinsIBA 10/2012 - 10/2008
2	Streptococcus pneumoniae plY proteinIBA 10/2005 - 02/2003
2	Toll-Like Receptor 4IBA 10/2005 - 02/2003
1	Complement System Proteins (Complement)IBA 01/2019
1	Type A Botulinum Toxins (Botox)FDA Link 01/2018
1	InterleukinsIBA 01/2017
1	InflammasomesIBA 01/2017
1	anthrax toxin (anthrax lethal factor)IBA 03/2016
1	Anti-Bacterial Agents (Antibiotics)IBA 03/2015
1	Vitamin D FDA LinkGeneric 10/2012
1	Hyaluronic Acid (Hyaluronan)IBA 10/2008
1	AntigensIBA 08/2006
1	VaccinesIBA 08/2006
1	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 10/2005
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2003